Recruiting NA INTERVENTIONAL NCT07648212

Does AI caries detection work differently for novices and experts — a randomized trial measuring the effect on the treatment threshold — a clinical trial (ClinicalTrials.gov)

University of Michigan Updated 2026-08-28

A randomized trial asking whether the effect of AI on detecting caries in radiographs depends on the experience of the person reading them, comparing detection and subsequent treatment decisions between early and experienced learners.

Trial overview (primary data)

  • StatusRecruiting
  • ConditionsCaries,Dental
  • InterventionsOTHER: Review of Radiograph Images
  • SponsorUniversity of Michigan
  • Target enrollment60 participants
  • Period2026-09-01 〜 2027-05-01

Key points

  • A randomized trial (target 60) on how AI for detecting proximal caries in radiographs changes detection and the treatment decisions that follow.
  • It compares early learners with experienced learners, starting from the premise that the effect of AI depends on the reader.
  • The intervention is the review of radiograph images, not the assignment of different procedures to patients.
  • Of the 803 AI-related clinical trials this site holds as of 2026-09-02, 25 relate to dentistry or caries.
  • Because more detection means more decisions about drilling, the effect does not stop at detection accuracy.

1From finding it to deciding whether to drill

Proximal caries, which form where teeth touch, are hard to see directly and are found through radiographs. But a shadow on an image does not automatically mean drilling. Early demineralization is often handled with fluoride application or watchful waiting, and where to set the point of switching to restorative treatment is left to the reader's judgment.

Introduce an AI that helps with detection and the effect does not stop at detection. If more lesions are found, the number of occasions demanding a decision about drilling rises too. This study takes that chain head-on.

2The hypothesis that the user changes the effect

Early learnersExperienced learners
Standards for reading are still formingA personal standard is already in place
May accept the AI prompt more readilyMay filter the prompt against their own judgment
More detection may move treatment decisionsThe threshold may hold even as detection rises
AI may shape how the standard formsAI may act as a means of confirmation

Hand out the same AI, and the result can differ with the recipient's level of training. Making that comparison the focus is somewhat unusual for an evaluation of medical AI. Most trials measure model accuracy or patient outcomes; the question here is how AI changes human judgment — and it starts from the premise that the change is not uniform.

The contrasts set out above are the hypotheses the study means to test, not results it has shown.

3Assigning readings, not procedures

The intervention is the review of radiograph images, not the assignment of different procedures to patients. It is classified as interventional, but what is actually manipulated is the condition of the reader. Detecting caries is among the most frequent judgments made in dentistry, and this design measures what happens when AI enters that judgment without exposing patients to treatment.

Of the 803 AI-related clinical trials this site holds as of 2026-09-02, 25 relate to dentistry or caries — not a large share.

4A question placed in the setting of education

Early readers are at the stage of building their own standards. What it does to the formation of those standards to receive AI prompts every day is a question separate from accuracy. Following the AI when it is right may be desirable, but whether the ability to suspect a lesion the AI did not flag still develops is unknown.

A target of 60 keeps this to early validation, yet the question it raises is not confined to dentistry: it appears wherever imaging AI enters a training setting.

Why it matters

Measuring the effect of AI by the user's level of training rather than by patient outcomes is a design that transfers to evaluating imaging AI in education and residency. Treating the chain from more detection to more treatment decisions also helps in estimating what deploying a support tool actually changes.

FAQ

Are patients assigned to different treatments in this trial?
No. The record describes the intervention as the review of radiograph images, not the assignment of procedures to patients. Treatment decisions should be discussed with a dentist.
Has AI been shown to reduce missed caries?
No. The study is at the stage of evaluating the impact on detection and treatment decisions; effectiveness has not been established.

Sources (primary)

Source: ClinicalTrials.gov (U.S. NIH/NLM, public domain). This site does not provide medical advice. Verify the latest and exact details with the official source. This site is not endorsed or certified by the NIH/NLM.

#Clinical trials#AI#Healthcare#Dentistry#Diagnostic imaging
Disclaimer: This site independently summarizes and classifies information based on official data sources. Always verify the latest and accurate information with the official sources. Content on finance, health, legal, and security is information, not advice. This site is not an official website of the U.S. government.