What the data shows
- In FY2025, the largest single NIH research award shown here is about ≈$82.5M to LEIDOS BIOMEDICAL RESEARCH, INC. (National Cancer Institute).
- The top 60 awards here total about ≈$1.44B — concentrated in large clinical networks, research centers, and infrastructure (data, biobanks, vaccine facilities).
- NIH funds on the order of tens of thousands of projects a year; this page shows only the largest by fiscal-year funding. For who wins the most overall, see the institution ranking.
NIH and its 27 Institutes & Centers (ICs)
NIH is the world's largest public biomedical research agency, funding on the order of tens of thousands of projects a year. It is organized into 27 Institutes and Centers (ICs) by disease and field — e.g., the National Cancer Institute (NCI), the National Institute of Allergy and Infectious Diseases (NIAID), the National Heart, Lung, and Blood Institute (NHLBI) — so the funding IC signals a project's focus area. Funding is mostly competitive extramural awards to universities and medical schools; this page shows those with the largest fiscal-year funding.
Largest research projects by award (FY2025)
| # | Project (official page ↗) | Institution | Funding IC | FY award |
|---|---|---|---|---|
| 1 | NCI-Frederick Operational Support 75N91019D00 | LEIDOS BIOMEDICAL RESEARCH, INC. (MD) | National Cancer Institute | ≈$82.5M |
| 2 | NHLBI Community Engagement Technical Assistance Center (CETAC) OT2HL158287 | WESTAT, INC. (MD) | National Heart Lung and Blood Institute | ≈$52.7M |
| 3 | MD NET 75N91019D00 | LEIDOS BIOMEDICAL RESEARCH, INC. (MD) | National Cancer Institute | ≈$42M |
| 4 | Division of Cancer Treatment and Diagnosis- Operational Task Order 75N91019D00 | LEIDOS BIOMEDICAL RESEARCH, INC. (MD) | National Cancer Institute | ≈$41.6M |
| 5 | All of Us Research Program Data and Research Center OT2OD035404 | VANDERBILT UNIVERSITY MEDICAL CENTER (TN) | NIH Office of the Director | ≈$40.7M |
| 6 | Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections UM1AI068636 | UNIVERSITY OF CALIFORNIA LOS ANGELES (CA) | National Institute of Allergy and Infectious Diseases | ≈$36.4M |
| 7 | SDMC: HIV Vaccine Trials Network UM1AI068635 | FRED HUTCHINSON CANCER CENTER (WA) | National Institute of Allergy and Infectious Diseases | ≈$35.8M |
| 8 | Partnering for Precision Medicine: A Collaborative Services Center for the All of Us Program OT2OD036464 | NATIONAL OPINION RESEARCH CENTER (IL) | NIH Office of the Director | ≈$35.5M |
| 9 | Health and Retirement Study: Yrs 35-40 U01AG009740 | UNIVERSITY OF MICHIGAN AT ANN ARBOR (MI) | National Institute on Aging | ≈$31.9M |
| 10 | The Health & Aging Brain Study - Health Disparities (HABS-HD) U19AG078109 | UNIVERSITY OF NORTH TEXAS HLTH SCI CTR (TX) | National Institute on Aging | ≈$31.8M |
| 11 | Biomedical Information Technology, Software Development, and Informatics Support CO25001001- | NATIONAL CANCER INSTITUTE | National Cancer Institute | ≈$30.9M |
| 12 | STRIDES OT2OD027852 | FOUR POINTS TECHNOLOGY, LLC (VA) | NIH Office of the Director | ≈$30.8M |
| 13 | HIV Vaccines Clinical Trials Network Leadership and Operations Center UM1AI068614 | FRED HUTCHINSON CANCER CENTER (WA) | National Institute of Allergy and Infectious Diseases | ≈$30.4M |
| 14 | HIV Vaccine Trials Network Laboratory Center UM1AI068618 | FRED HUTCHINSON CANCER CENTER (WA) | National Institute of Allergy and Infectious Diseases | ≈$30.4M |
| 15 | Data Coordinating Center for Type 1 Diabetes TrialNet U01DK106993 | UNIVERSITY OF SOUTH FLORIDA (FL) | National Institute of Diabetes and Digestive and Kidney Diseases | ≈$29.5M |
| 16 | Alzheimer's Clinical Trials Consortium (ACTC) U24AG057437 | UNIVERSITY OF SOUTHERN CALIFORNIA (CA) | National Institute on Aging | ≈$29.4M |
| 17 | Alzheimer's Disease Neuroimaging Initiative (ADNI4) U19AG024904 | NORTHERN CALIFORNIA INSTITUTE/RES/EDU (CA) | National Institute on Aging | ≈$28.9M |
| 18 | Immune Tolerance Network UM1AI109565 | BENAROYA RESEARCH INST AT VIRGINIA MASON (WA) | National Institute of Allergy and Infectious Diseases | ≈$27.3M |
| 19 | HIV Prevention Trials Network Leadership and Operations Center UM1AI068619 | FAMILY HEALTH INTERNATIONAL (NC) | National Institute of Allergy and Infectious Diseases | ≈$25.4M |
| 20 | All of Us Research Program Data and Research Center OT2OD035404 | VANDERBILT UNIVERSITY MEDICAL CENTER (TN) | NIH Office of the Director | ≈$25M |
| 21 | NIAID Division of AIDS (DAIDS) Clinical Site Monitoring 75N93021D00 | PPD DEVELOPMENT LP (NC) | National Institute of Allergy and Infectious Diseases | ≈$24.4M |
| 22 | DMID Clinical Research Operations & Management Support (CROMS) 75N93024C00 | TECHNICAL RESOURCES INTERNATIONAL, INC. (MD) | National Institute of Allergy and Infectious Diseases | ≈$22.3M |
| 23 | FY26 FFRDC LEASES 75N91019D00 | LEIDOS BIOMEDICAL RESEARCH, INC. (MD) | National Cancer Institute | ≈$22M |
| 24 | AI-driven Structure-enabled Antiviral Platform (ASAP) U19AI171399 | SLOAN-KETTERING INST CAN RESEARCH (NY) | National Institute of Allergy and Infectious Diseases | ≈$21.6M |
| 25 | Consortium for HIV/AIDS Vaccine Development UM1AI144462 | SCRIPPS RESEARCH INSTITUTE, THE (CA) | National Institute of Allergy and Infectious Diseases | ≈$21M |
| 26 | Induction of protective antibodies for HIV vaccine development UM1AI144371 | DUKE UNIVERSITY (NC) | National Institute of Allergy and Infectious Diseases | ≈$20.8M |
| 27 | Access for All in ALS (ALL ALS) West Clinical Coordinating Center OT2NS136939 | ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER (AZ) | National Institute of Neurological Disorders and Stroke | ≈$20.2M |
| 28 | CANCER TRIALS SUPPORT UNIT (CTSU) CORE SUPPORT SERVICES & THE CTSU ENTERPRISE OF SYSTEMS 75N91022D00 | WESTAT, INC. (MD) | National Cancer Institute | ≈$20M |
| 29 | Trans-Omics for Precision Medicine (TOPMed) Artificial Intelligence Coordinating Center (AI-CC) OT2HL180049 | WESTAT, INC. (MD) | National Heart Lung and Blood Institute | ≈$20M |
| 30 | SDMC: HIV Prevention Trials Network UM1AI068617 | FRED HUTCHINSON CANCER CENTER (WA) | National Institute of Allergy and Infectious Diseases | ≈$20M |
| 31 | Analyses to Reveal Trajectories and Early Markers of Imminent Shifts in Suicidal States UF1MH136537 | OHIO STATE UNIVERSITY (OH) | National Institute of Mental Health | ≈$19.5M |
| 32 | All of Us Biobank OT2OD039849 | MAYO CLINIC ROCHESTER (MN) | NIH Office of the Director | ≈$19.2M |
| 33 | Dynamic Cognitive Phenotypes for Prediction of Mental Health Outcomes in Serious Mental Illness UF1MH135991 | ALBERT EINSTEIN COLLEGE OF MEDICINE (NY) | National Institute of Mental Health | ≈$18.3M |
| 34 | NIAID/Division of AIDS: Regulatory Support Center 75N93021D00 | TECHNICAL RESOURCES INTERNATIONAL, INC. (MD) | National Institute of Allergy and Infectious Diseases | ≈$18M |
| 35 | CANCER THERAPY EVALUATION PROGRAM INFORMATICS & COMPUTER SUPPORT 31620120012 | CTIS, INC. (MD) | National Cancer Institute | ≈$18M |
| 36 | Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS) U19AG068054 | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (PA) | National Institute on Aging | ≈$18M |
| 37 | ECOG-ACRIN NCORP Research Base UG1CA189828 | ECOG-ACRIN MEDICAL RESEARCH FOUNDATION (PA) | National Cancer Institute | ≈$17.7M |
| 38 | ENABLING NCI CLINICAL & RESEARCH DATA SHARING 75N91019D00 | LEIDOS BIOMEDICAL RESEARCH, INC. (MD) | National Cancer Institute | ≈$17.7M |
| 39 | NHLBI Community Engagement Technical Assistance Center (CETAC) OT2HL158287 | WESTAT, INC. (MD) | National Heart Lung and Blood Institute | ≈$17.7M |
| 40 | Center for Multiomic Human Brain Cell Atlas UM1MH130994 | SALK INSTITUTE FOR BIOLOGICAL STUDIES (CA) | National Institute of Mental Health | ≈$17.6M |
| 41 | DEVELOPMENT OF TARGET CHARACTERIZATION METHODS FOR NOVEL CANCER MARKERS 75N91019D00 | LEIDOS BIOMEDICAL RESEARCH, INC. (MD) | National Cancer Institute | ≈$17.5M |
| 42 | Functionally guided adult whole brain cell atlas in human and NHP UM1MH130981 | ALLEN INSTITUTE (WA) | National Institute of Mental Health | ≈$17.3M |
| 43 | The National Health and Aging Trends Study and National Study of Caregiving U01AG032947 | JOHNS HOPKINS UNIVERSITY (MD) | National Institute on Aging | ≈$17.1M |
| 44 | ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration, Cycle 2 (ALLFTD2) U19AG063911 | MAYO CLINIC ROCHESTER (MN) | National Institute on Aging | ≈$17M |
| 45 | ED-LEAD: Emergency Departments LEading the transformation of Alzheimer's and Dementia care U19AG078105 | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (NY) | National Institute on Aging | ≈$16.8M |
| 46 | Statistical and Data Coordinating Center (SDCC) for Clinical Research in Infectious Diseases 75N93021C00 | THE EMMES COMPANY, LLC (MD) | National Institute of Allergy and Infectious Diseases | ≈$16.8M |
| 47 | ProCAN: Psychosis Risk Outcomes Compound Assessment Network U01MH137298 | YALE UNIVERSITY (CT) | National Institute of Mental Health | ≈$16.6M |
| 48 | Consortium for Advancing Management and Prevention of Cancer in People with HIV UM1CA121947 | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (NY) | National Cancer Institute | ≈$16.4M |
| 49 | DIAN-TU: Tau Next Generation Prevention Trial R01AG068319 | WASHINGTON UNIVERSITY (MO) | National Institute on Aging | ≈$16.3M |
| 50 | The National Dementia Workforce Study U54AG084520 | UNIVERSITY OF MICHIGAN AT ANN ARBOR (MI) | National Institute on Aging | ≈$16.2M |
| 51 | NIA AD/ADRD Health Care Systems Research Collaboratory U54AG063546 | BROWN UNIVERSITY (RI) | National Institute on Aging | ≈$16.1M |
| 52 | National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) U24AG021886 | INDIANA UNIVERSITY INDIANAPOLIS (IN) | National Institute on Aging | ≈$15.9M |
| 53 | HIV Vaccine Research and Development - NIAID DAIDS Vaccine Research Program AI23069001- | NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES | National Institute of Allergy and Infectious Diseases | ≈$15.7M |
| 54 | DIAN-TU Primary Prevention Trial U01AG059798 | WASHINGTON UNIVERSITY (MO) | National Institute on Aging | ≈$15.7M |
| 55 | Alzheimer's Prevention Initiative ADAD Colombia Trial Program R01AG086363 | BANNER HEALTH (AZ) | National Institute on Aging | ≈$15.5M |
| 56 | Alzheimer's Disease and Alzheimer's Disease Related Dementias in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Outcomes Study AD/ADRD Project U19AG078558 | COLUMBIA UNIVERSITY HEALTH SCIENCES (NY) | National Institute on Aging | ≈$15.5M |
| 57 | HABS-HD - Core C - Clinical Core U19AG078109 | UNIVERSITY OF NORTH TEXAS HLTH SCI CTR (TX) | National Institute on Aging | ≈$15.4M |
| 58 | Microbiology and Infectious Diseases Biological Research Repository (MID-BRR) 75N93024C00 | AMERICAN TYPE CULTURE COLLECTION (VA) | National Institute of Allergy and Infectious Diseases | ≈$15.4M |
| 59 | COG NCTN Network Group Operations Center Year 11 Extension U10CA180886 | PUBLIC HEALTH INSTITUTE (CA) | National Cancer Institute | ≈$15.2M |
| 60 | The Long Life Family Study U19AG063893 | WASHINGTON UNIVERSITY (MO) | National Institute on Aging | ≈$15.1M |
Project titles are official names in the original English. Follow each row's link to the official NIH RePORTER page for the abstract, research categories, and dates. NIH intramural block allocations are excluded, as they are not competitive awards.
Related data
FAQ
What does this page show?
NIH (National Institutes of Health) research projects funded in the most recent fiscal year, ordered by award amount — revealing where the largest U.S. biomedical investments went.
Are individual researchers named?
No. Principal investigator (PI) names and contacts are neither fetched nor shown (PII protection). Only the institution, project title, funding Institute/Center (IC), and amount appear.
What does the amount represent?
The funding (award amount) applied to that project in the fiscal year. Large clinical networks, research centers, and infrastructure programs tend to rank near the top.
I want totals per institution.
For award totals per institution (universities, research bodies), see the "Top NIH grant awardees" ranking. This page shows the largest awards per project; the ranking shows cumulative totals per institution.
What is the source? How can I see more?
Data comes from the official U.S. database NIH RePORTER (API). For each project's detail (abstract, research categories, dates), follow the link in each row to its official RePORTER page.
Sources (primary)
Source: NIH RePORTER (National Institutes of Health, official API, public domain). This site is not an official U.S. government source.